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Asst Prof YANG Liang
Deputy Research Director (Public Health & Medical Biofilms)
Nanyang Assistant Professor, School of Biological Sciences, NTU

Dr Yang investigates the role of signaling networks on regulating stress response in microbial biofilms. Biofilms are extremely resistant to antimicrobial agents and physical stress and cause a wide range of problems to industrial and hospital settings. The National Institute of Health (NIH) in the US estimates that 65-80% of microbial infections occurring in the human body are biofilm-mediated.  His research is dedicated to understanding intercellular signaling, interspecies interactions, and microbial evolution in the context of the biofilm lifestyle. At the fundamental level, both environmental stress and host immune-derived stress are examined for their impacts on inducing bacterial intercellular (quorum sensing) and intracellular (c-di-GMP) signaling mechanisms that coordinate biofilm formation and stress resistance. The combination of molecular biology and systems biology tools (transcriptomics and proteomics) has enabled us to examine how quorum sensing and c-di-GMP signaling mediates stress response in mono-species and multiple-species biofilms. At the applied level, high-throughput screening tools have been developed for discovering active compounds that can impair bacterial quorum sensing and c-di-GMP signaling. In addition, quorum sensing and c-di-GMP signaling are also being manipulated for improving the performance of industrial related bioreactors such as the microbial fuel cells. At the translational level, clinical isolates of major nosocomial infection causing species are monitored for their antibiotic resistance and genome contents. Comparative genomics and experimental evolution experiments are further employed to identify adaptive evolution of pathogens during chronic biofilm-associated infections. 

Dr Yang’s publications and citations can be found here: Yang Liang's Lab


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