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Prof Sven PETTERSSON
Deputy Research Director (Meta-'omics & Microbiomes)
Professor, Lee Kong Chian School of Medicine, NTU

Host–microbe interactions are as diverse as the organisms involved and can be accidental or obligatory, but the outcome is simple: health or disease. Studies over the last decade or so, of the bacteria-host relationship, have revealed considerable dynamic interactions which are affecting organ development, maturation and function of the host. Alterations in the composition and diversity of the host microbiome will therefore have an impact on disease development and progression. Indeed, association with diabetes, obesity, cardiovascular diseases and cancer has been reported. This new perspective is a paradigm shift leading away from the conventional "one-microbe, one-disease" theory of infection. Rather, a systems biology approach is required if we aim to decipher the molecular mechanism by which microbes can modulate host physiology. Professor Pettersson studies the bilateral signaling pathways and molecules by which the microbiome and the host communicate, with a particular interest in the gut-to-brain dialogue.


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